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Methylene Blue

The Science Behind Methylene Blue: A Forgotten Compound with Modern Potential

Methylene Blue (MB) is a compound with over 100 years of pharmaceutical history. Originally synthesized in the 19th century, it was the first fully synthetic drug used in medicine and is still listed as an essential medicine by the World Health Organization (WHO). Though it began as a treatment for methemoglobinemia, a condition in which hemoglobin can’t properly release oxygen to body tissues, its diverse mechanisms of action have since made it a promising candidate for numerous health conditions.

How Methylene Blue Works

Cellular Respiration & Oxygen Delivery
Methylene Blue restores the blood’s ability to carry oxygen by converting methemoglobin (which cannot bind oxygen) back into functional hemoglobin. This improves oxygen availability throughout the body.
Mitochondrial Function
MB acts as an alternative electron carrier in the electron transport chain. This helps generate more ATP, the energy currency of the cell, especially under stress conditions where mitochondria are dysfunctional. It’s particularly beneficial in energy-demanding tissues like the brain and nerves.
Neuroprotection & Brain Health
MB crosses the blood-brain barrier and accumulates in brain tissue. It reduces oxidative stress, boosts mitochondrial respiration, and protects neurons from damage. This combination makes it a compelling candidate for managing cognitive decline, neurodegeneration, and brain fog.
Antioxidant & Free Radical Scavenger
Methylene Blue acts both as a pro-oxidant and antioxidant depending on cellular needs. It neutralizes reactive oxygen species (ROS), reducing oxidative stress, one of the leading contributors to aging, inflammation, and chronic disease.
Antimicrobial Action
Its origins as a synthetic dye include powerful antimicrobial effects. MB is capable of neutralizing a range of pathogens and is still used today as a component of photodynamic therapy for infection control.

Proven Benefits, Backed by Research

Focus & Memory: Enhances ATP production in neurons, promoting neurogenesis and synaptic plasticity.
Mood & Mental Health: Modulates neurotransmitters like serotonin and dopamine, showing promise in reversing depression and stabilizing mood.
Energy & Performance: Improves mitochondrial output, supporting better physical and mental endurance.
Anti-aging & Cell Repair: Protects DNA and cell membranes from oxidative damage, aiding tissue repair and cellular longevity.
Wound Healing: Topical MB has been used to treat burns and ulcers due to its anti-inflammatory and tissue-repairing properties.

Potential Applications Under Study

Though not officially approved for treatment beyond methemoglobinemia, thousands of peer-reviewed studies and ongoing clinical trials suggest MB may have therapeutic value in:

Alzheimer’s disease: Reduces tau protein aggregation and boosts memory performance
Stroke recovery: Enhances neuronal repair and oxygen delivery
ADHD: Supports dopamine balance and cognitive control
Epilepsy: Protects neurons from oxidative stress linked to seizures
Certain Cancers: Promotes cancer cell apoptosis (cell death) under specific conditions when used adjunctively

Many doctors and clinics around the world are already exploring Methylene Blue in off-label protocols, and countless individuals have shared compelling anecdotal results online.

At AP Labs, we supply USP Grade Methylene Blue, tested by two independent laboratories for purity, heavy metals, and microbial safety.

Always consult a healthcare provider before starting any new supplement, especially if you are taking medication or have a pre-existing condition.

Interested in trying Methylene Blue for yourself?

We offer USP Grade, double third-party tested Methylene Blue you can trust.

Notable Studies

A controlled trial of methylene blue in severe depressive illness

Neurometabolic mechanisms for memory enhancement and neuroprotection

Methylene Blue Induces Antioxidant Defense and Reparation of Mitochondrial

What is Methylene Blue?

Methylene Blue is a synthetic compound made from phenothiazine, a chemical base.

Originally developed to treat blood disorders in human patients, but now it attracts almost all of its attention for the ability that it has in improving brain energy and protecting cells from damage by enhancing one’s mitochondrial function.

Initially used as a dye in the textile industry and later for medical purposes, such as treating methemoglobinemia and urinary tract infections. However, it wasn’t until recent years that scientists began to delve deeper into its potential for treating cancer. However, not replacing traditional chemotherapy or radiation treatments, the promise in cancer treatment has sparked wide interest in the medical community, as it shows the potential to not only manage the side effects of cancer but also directly target cancer cells.

Don’t forget that our Methylene Blue is USP Grade.

What are the benefits of Methylene Blue?

Over the years, research has highlighted many benefits. From cognitive functions to improving slow brain atrophy among many more but we’ve compiled a list of the most noticable improvements below:

Anti Microbial
Boosts Energy
Anti Depressant
Memory & Focus
Removes Free Radicals
Anti-Aging

Studies have shown that our product helps against congnitive diseases like Alzheimer’s by maintaining a person’s brain health over a period of time.

By optimising a person’s mitochondrial function, it demonstrates the impact on improving neuronal energy efficiency and congitive performance in individuals.

Perfect for Athletes

A high amount of athletes that take part in full-contact sports like rugby, boxing, hockey, and football have experienced and/or felt the effect of head trauma. Personal accounts have witnessed the decline of congitive function after a rough session or game. This is where Methylene Blue comes into play.

This has changed from being drowsy, running red lights after the session, to being perfectly fine right from the get go. It has shown the improvements a couple of days after starting to use.

Where can I buy Methylene Blue?

Methylene Blue is for sale in our very own store located in South Africa you can follow the link below to get you own bottle. Keep in mind.. the more you buy, the more you save!

Buy Methylene Blue in South Africa

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What’s contained in the bottle?

Each bottle contains 450mg of Methylene Blue, with 30 servings. Each serving contains 15mg.
Our bottles are packaged with stickers, that you can use to get creative with. Showcasing your love for the product.

Ensuring its purity and confirming its quality as a pharmaceutical-grade supplement. It should not be consumed unless it’s verified as USP grade, as it may contain high levels of heavy metals and toxic chemicals.